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Cell Mol Life Sci. 2014 Mar;71(6):1033-43. doi: 10.1007/s00018-013-1486-y. Epub 2013 Oct 15.

B Lymphocytes in obesity-related adipose tissue inflammation and insulin resistance.

Author information

1
Department of Pathology, Toronto General Hospital, University Health Network, University of Toronto, Eaton Wing, 11E - 424A, 200 Elizabeth Street, Toronto, ON, M5G 2C4, Canada.

Abstract

Obesity-related insulin resistance is a chronic inflammatory condition that often gives rise to type 2 diabetes (T2D). Much evidence supports a role for pro-inflammatory T cells and macrophages in promoting local inflammation in tissues such as visceral adipose tissue (VAT) leading to insulin resistance. More recently, B cells have emerged as an additional critical player in orchestrating these processes. B cells infiltrate VAT and display functional and phenotypic changes in response to diet-induced obesity. B cells contribute to insulin resistance by presenting antigens to T cells, secreting inflammatory cytokines, and producing pathogenic antibodies. B cell manipulation represents a novel approach to the treatment of obesity-related insulin resistance and potentially to the prevention of T2D. This review summarizes the roles of B cells in governing VAT inflammation and the mechanisms by which these cells contribute to altered glucose homeostasis in insulin resistance.

PMID:
24127133
PMCID:
PMC3954849
DOI:
10.1007/s00018-013-1486-y
[Indexed for MEDLINE]
Free PMC Article

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