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Angew Chem Int Ed Engl. 2013 Dec 2;52(49):13028-32. doi: 10.1002/anie.201305784. Epub 2013 Oct 14.

Development of azo-based fluorescent probes to detect different levels of hypoxia.

Author information

1
Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan).

Abstract

Let it shine: New hypoxia-sensitive fluorescent probes were developed; they consist of a rhodamine moiety with an azo group directly conjugated to the fluorophore. Because of an ultrafast conformational change around the NN bond, the compounds are nonfluorescent under normoxia. However, under hypoxia, the azo group is reduced, and a strongly fluorescent rhodamine derivative is released.

KEYWORDS:

azo compounds; bioorganic chemistry; fluorescent probes; imaging agents; oxygen concentration

PMID:
24127124
DOI:
10.1002/anie.201305784
[Indexed for MEDLINE]

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