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Antimicrob Agents Chemother. 2014;58(1):574-6. doi: 10.1128/AAC.01462-13. Epub 2013 Oct 14.

Efflux inhibition with verapamil potentiates bedaquiline in Mycobacterium tuberculosis.

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1
Center for Tuberculosis Research, Department of Medicine, JHU, Baltimore, Maryland, USA.

Abstract

Drug efflux is an important resistance mechanism in Mycobacterium tuberculosis. We found that verapamil, an efflux inhibitor, profoundly decreases the MIC of bedaquiline and clofazimine to M. tuberculosis by 8- to 16-fold. This exquisite susceptibility was noted among drug-susceptible and drug-resistant clinical isolates. Thus, efflux inhibition is an important sensitizer of bedaquiline and clofazimine, and efflux may emerge as a resistance mechanism to these drugs.

PMID:
24126586
PMCID:
PMC3910722
DOI:
10.1128/AAC.01462-13
[Indexed for MEDLINE]
Free PMC Article
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