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Cancer Discov. 2013 Oct;3(10):1103-4. doi: 10.1158/2159-8290.CD-13-0481.

Hypoxia signaling--license to metastasize.

Author information

1
1Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York; and 2Howard Hughes Medical Institute, Chevy Chase, Maryland.

Abstract

Hypoxia-inducible factors (HIF) have long been linked to malignant tumor phenotypes in various cancer types, and several downstream mediators of HIF action are deregulated in metastatic carcinomas. A new study links hypoxia-induced collagen remodeling to sarcoma progression, providing evidence for unifying mechanisms of carcinoma and sarcoma metastasis.

PMID:
24124230
PMCID:
PMC3889127
DOI:
10.1158/2159-8290.CD-13-0481
[Indexed for MEDLINE]
Free PMC Article
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