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Angew Chem Int Ed Engl. 2013 Dec 2;52(49):12901-4. doi: 10.1002/anie.201307481. Epub 2013 Oct 10.

Thiols and selenols as electron-relay catalysts for disulfide-bond reduction.

Author information

1
Department of Chemistry, 1101 University Avenue, University of Wisconsin-Madison, Madison, WI 53706 (USA) http://www.biochem.wisc.edu/faculty/raines/lab.

Abstract

Pass them on! Dithiobutylamine immobilized on a resin is a useful reagent for the reduction of disulfide bonds. Its ability to reduce a disulfide bond in a protein is enhanced greatly if used along with a soluble strained cyclic disulfide or mixed diselenide that relays electrons from the resin to the protein. This electron-relay catalysis system provides distinct advantages over the use of excess soluble reducing agent alone.

KEYWORDS:

heterogeneous catalysis; proteins; redox chemistry; selenium; sulfur

PMID:
24123634
PMCID:
PMC3885359
DOI:
10.1002/anie.201307481
[Indexed for MEDLINE]
Free PMC Article

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