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Anticancer Res. 2013 Oct;33(10):4373-80.

Enhancing the activity of cannabidiol and other cannabinoids in vitro through modifications to drug combinations and treatment schedules.

Author information

1
Dept of Oncology, Division of Clinical Sciences, St. George's, University of London, 2nd Floor, Jenner Wing, London, SW17 0RE, U.K. w.liu@sgul.ac.uk.

Abstract

Cannabinoids are the bioactive components of the Cannabis plant that display a diverse range of therapeutic qualities. We explored the activity of six cannabinoids, used both alone and in combination in leukaemic cells. Cannabinoids were cytostatic and caused a simultaneous arrest at all phases of the cell cycle. Re-culturing pre-treated cells in drug-free medium resulted in dramatic reductions in cell viability. Furthermore, combining cannabinoids was not antagonistic. We suggest that the activities of some cannabinoids are influenced by treatment schedules; therefore, it is important to carefully select the most appropriate strategy in order to maximise their efficacy.

KEYWORDS:

Cannabinoids; drug combination; drug schedule; leukaemia

PMID:
24123005
[Indexed for MEDLINE]

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