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J Pathol. 2014 Jan;232(2):112-20. doi: 10.1002/path.4277.

Dendritic cells in IBD pathogenesis: an area of therapeutic opportunity?

Author information

1
Genentech, Inc, South San Francisco, CA, 94080, USA.

Abstract

Dysfunction of the mucosal immune system plays an important role in inflammatory bowel disease (IBD) pathogenesis. Dendritic cells are emerging as central players based on both our increasing understanding of how genetic susceptibility impacts the mucosal immune system and the key role of dendritic cells in regulating response to gut microflora. We discuss areas of therapeutic opportunity in this evolving landscape.

KEYWORDS:

Crohn's disease; colitis; dendritic cell; inflammation; inflammatory bowel disease; mucosal immunity

PMID:
24122796
PMCID:
PMC4285849
DOI:
10.1002/path.4277
[Indexed for MEDLINE]
Free PMC Article

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