Format

Send to

Choose Destination
J Alzheimers Dis. 2014;39(1):163-7. doi: 10.3233/JAD-131040.

Cerebral cortical microinfarcts at 7Tesla MRI in patients with early Alzheimer's disease.

Author information

1
Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
2
Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands.
3
Department of Geriatrics, University Medical Center Utrecht, Utrecht, The Netherlands.
4
Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands.

Abstract

Cerebral microinfarcts (CMIs) are a common finding in neuropathological studies of aging and dementia. Recently, it has become possible to detect CMIs in vivo. We studied CMI occurrence in 29 patients with mild cognitive impairment or early Alzheimer's disease (AD) and 22 non-demented individuals on 7Tesla MRI. CMI occurrence in patients (55%) and controls (45%) was not significantly different. In patients, CMI number tended to be related to microbleed number (p = 0.07). This first in vivo study of CMIs in early AD does not confirm findings from autopsy studies. Further studies are needed to clarify the role of CMIs in AD.

KEYWORDS:

Alzheimer's disease; magnetic resonance imaging; microbleeds; microinfarcts; mild cognitive impairment

PMID:
24121967
DOI:
10.3233/JAD-131040
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for IOS Press
Loading ...
Support Center