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Nat Genet. 2013 Dec;45(12):1428-30. doi: 10.1038/ng.2800. Epub 2013 Oct 13.

Frequent truncating mutations of STAG2 in bladder cancer.

Author information

1
1] Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC, USA. [2] Department of Pathology, University of California, San Francisco, San Francisco, California, USA.

Abstract

Here we report the discovery of truncating mutations of the gene encoding the cohesin subunit STAG2, which regulates sister chromatid cohesion and segregation, in 36% of papillary non-invasive urothelial carcinomas and 16% of invasive urothelial carcinomas of the bladder. Our studies suggest that STAG2 has a role in controlling chromosome number but not the proliferation of bladder cancer cells. These findings identify STAG2 as one of the most commonly mutated genes in bladder cancer.

PMID:
24121789
PMCID:
PMC3875130
DOI:
10.1038/ng.2800
[Indexed for MEDLINE]
Free PMC Article

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