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J Invest Dermatol. 2014 Mar;134(3):809-817. doi: 10.1038/jid.2013.415. Epub 2013 Oct 11.

Catecholamine stress alters neutrophil trafficking and impairs wound healing by β2-adrenergic receptor-mediated upregulation of IL-6.

Author information

1
Department of Biomedical Engineering, University of California at Davis, Davis, California, USA; Department of Biological Sciences, Kent State University, Kent, Ohio, USA.
2
Department of Dermatology, School of Medicine, University of California at Davis, Davis, California, USA.
3
School of Veterinary Medicine: Pathology, Microbiology, Immunology, University of California at Davis School of Veterinary Medicine, Davis, California, USA.
4
Department of Dermatology, School of Medicine, University of California at Davis, Davis, California, USA; Shriners Hospital of Northern California, Sacramento, California, USA.
5
Department of Biomedical Engineering, University of California at Davis, Davis, California, USA.
6
Department of Dermatology, School of Medicine, University of California at Davis, Davis, California, USA; Dermatology Section, Department of Veterans Affairs, Northern California Health Care System, Mather, California, USA. Electronic address: rrisseroff@ucdavis.edu.

Abstract

Stress-induced hormones can alter the inflammatory response to tissue injury; however, the precise mechanism by which epinephrine influences inflammatory response and wound healing is not well defined. Here we demonstrate that epinephrine alters the neutrophil (polymorphonuclear leukocyte (PMN))-dependent inflammatory response to a cutaneous wound. Using noninvasive real-time imaging of genetically tagged PMNs in a murine skin wound, chronic, epinephrine-mediated stress was modeled by sustained delivery of epinephrine. Prolonged systemic exposure of epinephrine resulted in persistent PMN trafficking to the wound site via an IL-6-mediated mechanism, and this in turn impaired wound repair. Further, we demonstrate that β2-adrenergic receptor-dependent activation of proinflammatory macrophages is critical for epinephrine-mediated IL-6 production. This study expands our current understanding of stress hormone-mediated impairment of wound healing and provides an important mechanistic link to explain how epinephrine stress exacerbates inflammation via increased number and lifetime of PMNs.

PMID:
24121404
PMCID:
PMC4013292
DOI:
10.1038/jid.2013.415
[Indexed for MEDLINE]
Free PMC Article

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