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Biosens Bioelectron. 2014 Mar 15;53:31-6. doi: 10.1016/j.bios.2013.09.033. Epub 2013 Sep 21.

Functional brain fluorescence plurimetry in rat by implantable concatenated CMOS imaging system.

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Division of Molecular Brain Science, Research Institute of Traditional Asian Medicine, Kinki University, Osaka-Sayama, Osaka 589 8511, Japan. Electronic address:


Measurement of brain activity in multiple areas simultaneously by minimally invasive methods contributes to the study of neuroscience and development of brain machine interfaces. However, this requires compact wearable instruments that do not inhibit natural movements. Application of optical potentiometry with voltage-sensitive fluorescent dye using an implantable image sensor is also useful. However, the increasing number of leads required for the multiple wired sensors to measure larger domains inhibits natural behavior. For imaging broad areas by numerous sensors without excessive wiring, a web-like sensor that can wrap the brain was developed. Kaleidoscopic potentiometry is possible using the imaging system with concatenated sensors by changing the alignment of the sensors. This paper describes organization of the system, evaluation of the system by a fluorescence imaging, and finally, functional brain fluorescence plurimetry by the sensor. The recorded data in rat somatosensory cortex using the developed multiple-area imaging system compared well with electrophysiology results.


CMOS image sensor; Fluorescence potentiometry; Functional brain imaging; Implantable microsensor; Rat somatosensory cortex; Voltage-sensitive dye

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