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Bioorg Med Chem Lett. 2013 Dec 1;23(23):6421-6. doi: 10.1016/j.bmcl.2013.09.049. Epub 2013 Sep 25.

Improved inhibitory activities against tumor-cell migration and invasion by 15-benzylidene substitution derivatives of andrographolide.

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1
Department of Biotechnology, Zhengzhou University, Zhengzhou 450001, PR China.

Abstract

In the present study, andrographolide (Andro, 1) derivatives were screened to identify potent inhibitors against tumor-cell migration and invasion, and associated structure-activity relationships were studied. Compared to 1, compounds 8a-8d exhibited more potent activities against migration in SGC-7901, PC-3, A549, HT-29 and Ec109 cell lines. Improved activities against tumor-cell migration and invasion were proved to be associated with the down-regulation of MMPs.

KEYWORDS:

Andrographolide; Derivative; Invasion; MMP-9; Migration

PMID:
24120543
DOI:
10.1016/j.bmcl.2013.09.049
[Indexed for MEDLINE]
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