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Microbes Infect. 2014 Jan;16(1):61-6. doi: 10.1016/j.micinf.2013.09.005. Epub 2013 Oct 8.

Constitutive mosaic aneuploidy is a unique genetic feature widespread in the Leishmania genus.

Author information

1
University Montpellier 1, Faculty of Medicine, Laboratory of Parasitology-Mycology, Montpellier, France; CNRS 5290, IRD 224, University Montpellier 1&2 (UMR "MiVEGEC"), Montpellier, France.
2
University Montpellier 1, Faculty of Medicine, Laboratory of Parasitology-Mycology, Montpellier, France; CNRS 5290, IRD 224, University Montpellier 1&2 (UMR "MiVEGEC"), Montpellier, France; Centre Hospitalier Universitaire (University Hospital Centre), Montpellier, France.
3
University Montpellier 1, Faculty of Medicine, Laboratory of Parasitology-Mycology, Montpellier, France.
4
CNRS 5290, IRD 224, University Montpellier 1&2 (UMR "MiVEGEC"), Montpellier, France.
5
University Montpellier 1, Faculty of Medicine, Laboratory of Parasitology-Mycology, Montpellier, France; CNRS 5290, IRD 224, University Montpellier 1&2 (UMR "MiVEGEC"), Montpellier, France; Centre Hospitalier Universitaire (University Hospital Centre), Montpellier, France. Electronic address: yvon.sterkers@univ-montp1.fr.

Abstract

Using fluorescence in situ hybridization, we determined the ploidy of four species of Leishmania: Leishmania infantum, Leishmania donovani, Leishmania tropica and Leishmania amazonensis. We found that each cell in a strain possesses a combination of mono-, di- and trisomies for all chromosomes; ploidy patterns were different among all strains/species. These results extend those we previously described in Leishmania major, demonstrating that mosaic aneuploidy is a genetic feature widespread to the Leishmania genus. In addition to the genetic consequences induced by this mosaicism, the apparent absence of alternation between haploid/diploid stages questions the modality of genetic exchange in Leishmania sp.

KEYWORDS:

Aneuploidy; Chromosome; Genetic exchange; Genome; Leishmania; Mosaicism

PMID:
24120456
DOI:
10.1016/j.micinf.2013.09.005
[Indexed for MEDLINE]

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