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Behav Brain Res. 2013 Nov 15;257:178-81. doi: 10.1016/j.bbr.2013.10.001. Epub 2013 Oct 10.

Narp knockout mice show normal reactivity to novelty but attenuated recovery from neophobia.

Author information

1
Department of Psychiatry and Behavioral Sciences Johns Hopkins School of Medicine, Baltimore, MD 21205, USA. Electronic address: ablouin@scripps.edu.

Abstract

Narp knockout (KO) mice demonstrate cognitive inflexibility and addictive behavior, which are associated with abnormal reactivity to a novel stimulus. To assess reactivity to novelty, we tested Narp KO and wild-type (WT) mice on a neophobia procedure. Both Narp KO and WT mice showed a similar decrease in consumption upon initial exposure to a novel flavor, but Narp KO mice did not increase consumption with subsequent exposures to the novel flavor like the WT mice. Therefore, Narp KO mice do not have abnormal reactivity to novelty but show deficits in adapting behavior to reflect the updated value of a stimulus.

KEYWORDS:

Addiction; Extinction; Narp; Neophobia; Novelty; Recovery from neophobia

PMID:
24120400
PMCID:
PMC3867371
DOI:
10.1016/j.bbr.2013.10.001
[Indexed for MEDLINE]
Free PMC Article
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