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Sleep Med Rev. 2014 Jun;18(3):261-71. doi: 10.1016/j.smrv.2013.07.005. Epub 2013 Oct 9.

A review of the effects of pregabalin on sleep disturbance across multiple clinical conditions.

Author information

1
Division of Sleep Medicine and Research Center, Henry Ford Health System, 2799 West Grand Boulevard, Detroit, MI 48202, USA. Electronic address: troth1@hfhs.org.
2
Women's Health Research Program, University of Cincinnati, 260 Stetson Street, Suite 3200, Cincinnati, OH 45219, USA. Electronic address: Lesley.Arnold@uc.edu.
3
Sleep Research Institute, Alberto Alcocer 19, 28036 Madrid, Spain. Electronic address: dgb@iis.es.
4
Pfizer Inc., 235 East 42nd Street, New York, NY 10017, USA. Electronic address: malca.resnick@pfizer.com.
5
Pfizer Inc., 235 East 42nd Street, New York, NY 10017, USA. Electronic address: andrew.clair@pfizer.com.

Abstract

Pregabalin is approved for the treatment of a variety of clinical conditions and its analgesic, anxiolytic and anticonvulsant properties are well documented. Pregabalin's effects on sleep, however, are less well known. This review summarizes the published data on the effects of pregabalin on sleep disturbance associated with neuropathic pain, fibromyalgia, restless legs syndrome, partial onset seizures and general anxiety disorder. The data demonstrate that pregabalin has a positive benefit on sleep disturbance associated with several different clinical conditions. Polysomnographic data reveal that pregabalin primarily affects sleep maintenance. The evidence indicates that pregabalin has a direct effect on sleep that is distinct from its analgesic, anxiolytic and anticonvulsant effects.

KEYWORDS:

Patient-report; Polysomnography; Pregabalin; Sleep disturbance

PMID:
24119681
DOI:
10.1016/j.smrv.2013.07.005
[Indexed for MEDLINE]
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