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Trends Cell Biol. 2014 Feb;24(2):136-43. doi: 10.1016/j.tcb.2013.09.001. Epub 2013 Oct 9.

Getting rid of DNA methylation.

Author information

1
Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.
2
Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK. Electronic address: amanda.fisher@csc.mrc.ac.uk.

Abstract

Methylation of cytosine within DNA is associated with transcriptional repression and genome surveillance. In plants and animals, conserved pathways exist to establish and maintain this epigenetic mark. Mechanisms underlining its removal are, however, diverse and controversial and can depend on DNA synthesis (passive) or be independent of it (active). Ten-eleven translocation (Tet)-mediated conversion of 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) has recently been evoked as a possible mechanism in the initiation of active and passive DNA demethylation. This review discuses the recent progress in this exciting area.

PMID:
24119665
DOI:
10.1016/j.tcb.2013.09.001
[Indexed for MEDLINE]

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