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Trends Cell Biol. 2013 Dec;23(12):652-62. doi: 10.1016/j.tcb.2013.09.004. Epub 2013 Oct 10.

HIV trafficking in host cells: motors wanted!

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Institut Curie, Centre de Recherche, 26 rue d'Ulm, 75248 Paris Cedex 05, France; INSERM, U932, 26 rue d'Ulm, 75248 Paris Cedex 05, France.


Throughout the viral replication cycle, viral proteins, complexes, and particles need to be transported within host cells. These transport events are dependent on the host cell cytoskeleton and molecular motors. However, the mechanisms by which virus is trafficked along cytoskeleton filaments and how molecular motors are recruited and regulated to guarantee successful integration of the viral genome and production of new viruses has only recently begun to be understood. Recent studies on HIV have identified specific molecular motors involved in the trafficking of these viral particles. Here we review recent literature on the transport of HIV components in the cell, provide evidence for the identity and role of molecular motors in this process, and highlight how these trafficking events may be related to those occurring with other viruses.


actin; cytoskeleton; dynein; kinesin; microtubule; myosin; retrovirus

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