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Int J Med Microbiol. 2014 Jan;304(1):93-9. doi: 10.1016/j.ijmm.2013.08.007. Epub 2013 Sep 4.

Defensin-based anti-infective strategies.

Author information

1
Institute of Medical Microbiology, Immunology and Parasitology - Pharmaceutical Microbiology Section, University of Bonn, 53105 Bonn, Germany.
2
Institute of Medical Microbiology, Immunology and Parasitology - Pharmaceutical Microbiology Section, University of Bonn, 53105 Bonn, Germany. Electronic address: hgsahl@uni-bonn.de.

Abstract

Cationic and amphiphilic peptides are widely distributed in eukaryotic organisms and constitute a first line of host defense against invading pathogens. Some of these host defense peptides (HDPs) combine specific antibiotic activities with modulation of immune responses. Moreover, they are active against bacteria resistant to conventional antibiotics and show only modest resistance development under in vitro selection pressure. Based on these features, HDPs and particularly defensins are considered a promising source of novel anti-infective agents. This review summarizes the current knowledge about defensins from different kingdoms and discusses their potential for therapeutic application.

KEYWORDS:

Antimicrobial peptides; Defensins; Host defense peptides; Immunomodulation; Target-mediated antibiotic activity

PMID:
24119539
DOI:
10.1016/j.ijmm.2013.08.007
[Indexed for MEDLINE]

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