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Am J Emerg Med. 2014 Jan;32(1):71-4. doi: 10.1016/j.ajem.2013.08.063. Epub 2013 Oct 8.

Risk of intracranial injury after minor head trauma in patients with pre-injury use of clopidogrel.

Author information

1
Department of Emergency Medicine, Section of Medical Toxicology, University of Southern California, Los Angeles, CA, USA. Electronic address: mdlevine@usc.edu.
2
Department of Emergency Medicine, University of Southern California, Los Angeles, CA, USA.
3
Department of Emergency Medicine, Maricopa Medical Center, Phoenix, AZ, USA.
4
Department of Emergency Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Abstract

BACKGROUND:

Clopidogrel is an adenosine diphosphate receptor antagonist. The risk of intracranial hemorrhage following minor head trauma in patients with pre-injury use of clopidogrel has not been fully determined.

METHODS:

This case-controlled study examined the effects of pre-injury use of clopidogrel in adult (age 14 years and older) patients with minor head trauma.

RESULTS:

During the study period, 1660 patients head computed tomography scans were performed in the emergency department, of which 658 met inclusion criteria. Intracranial hemorrhage was noted in 30% of patients on clopidogrel, compared with 2.2% of those patients without pre-injury use of clopidogrel. After performing a logistic regression analysis for confounders, the pre-injury use of clopidogrel was significantly associated with intracranial hemorrhage in this study population (OR 16.7; 95% CI 1.71-162.7).

CONCLUSION:

The use of clopidogrel is associated with a significantly increased risk of developing intracranial hemorrhage following minor trauma.

PMID:
24119451
DOI:
10.1016/j.ajem.2013.08.063
[Indexed for MEDLINE]

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