Format

Send to

Choose Destination
Histopathology. 2014 Feb;64(3):399-404. doi: 10.1111/his.12262. Epub 2013 Oct 11.

Total submission of pelvic lymphadenectomy tissues removed during radical prostatectomy for prostate cancer increases lymph node yield and detection of micrometastases.

Author information

1
Aquesta Pathology, Brisbane, QLD, Australia; Royal Brisbane Hospital, Brisbane, QLD, Australia.

Abstract

AIMS:

The detection of lymph node metastases has prognostic and therapeutic implications for patients undergoing radical prostatectomy for prostate cancer. Macroscopic identification of pelvic lymph nodes in surgical lymphadenectomy specimens can be difficult, with a potential for incomplete submission of lymph nodes for microscopic examination. This study was undertaken to determine whether complete sampling of lymphadenectomy specimens would improve the detection of metastatic disease in patients undergoing radical prostatectomy.

METHODS AND RESULTS:

We examined 109 pelvic lymphadenectomies accompanying radical prostatectomy specimens to assess the benefit of complete submission of the lymph node packets to detect extra lymph nodes and metastatic disease. We found that blocking the residual tissue, after all palpable lymph nodes had been identified, increased the mean number of lymph nodes from 3.8 to 10.8, with an average of 0.84 macroscopically undetectable nodes being recovered per block submitted. Metastatic prostate cancer was identified in eight cases, one of which had cancer in an impalpable lymph node only.

CONCLUSIONS:

Submission of all pelvic lymphadenectomy tissue for histological examination improves the yield of lymph nodes and the detection of metastatic prostate cancer.

KEYWORDS:

lymph nodes; lymphadenectomy; metastasis; prognosis; prostate adenocarcinoma; radical prostatectomy

PMID:
24118022
DOI:
10.1111/his.12262
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center