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Immunol Rev. 2013 Nov;256(1):107-17. doi: 10.1111/imr.12117.

The role of the cytoskeleton at the immunological synapse.

Author information

1
Cambridge Institute for Medical Research, University of Cambridge Biomedical Campus, Cambridge, UK.

Abstract

It has been over 30 years since the reorganization of both the microtubule network and a 'peculiar actin polarization' was reported at the contact area of cytotoxic T lymphocytes interacting with target cells. Since that time, hundreds of studies have been published in an effort to elucidate the structure and function of the microtubule network and the actin cytoskeleton in T-cell activation, migration, and effector function at the interface between a T cell and its cognate antigen-presenting cell or target cell. This interface has become known as the immunological synapse, and this review examines some of the roles played by the cytoskeleton at the synapse.

KEYWORDS:

T lymphocytes; cytoskeleton; synapse

PMID:
24117816
PMCID:
PMC4312978
DOI:
10.1111/imr.12117
[Indexed for MEDLINE]
Free PMC Article

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