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Ann N Y Acad Sci. 2013 Oct;1300:43-52. doi: 10.1111/nyas.12231.

Respiratory manifestations of gastroesophageal reflux disease.

Author information

1
Department of Medicine/Pulmonary Allergy & Critical Care, University of Alabama at Birmingham, Birmingham, Alabama.
2
Department of Otolaryngology, Northshore Hospital, Auckland, New Zealand.
3
Division of Laryngology & Professional Voice, Department of Otolaryngology & Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin.
4
Department of Surgery, University of Washington, Seattle, Washington.
5
Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Homen's Hospital, Harvard Medical School, Cambridge, Massachusetts.

Abstract

Gastroesophageal reflux disease (GERD) is highly associated with a range of respiratory symptoms, arising from a variety of etiologies. The following commentaries on respiratory manifestations of GERD address evidence for a role of a vagally mediated bronchoconstriction reflex in the development of asthma; the direct effects of airway obstruction on lower esophageal sphincter (LES) pressure and reflux episodes; the mechanisms by which reflux may play roles in chronic cough and airway stenosis; the limited efficacy of laparoscopic antireflux surgery (LARS) in improving GERD-related respiratory symptoms; the search for a marker for microaspiration and reflux-induced airway disease; and the potential of proton pump inhibitor (PPI) treatment for patients presenting with asthma and GERD.

KEYWORDS:

GERD; asthma; bronchoconstriction; extra-esophageal reflux

PMID:
24117633
DOI:
10.1111/nyas.12231
[Indexed for MEDLINE]

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