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Semin Ophthalmol. 2015;30(5-6):420-2. doi: 10.3109/08820538.2013.833267. Epub 2013 Oct 11.

Muir-Torre Syndrome in a Middle-Aged Chinese Patient with Sebaceous Carcinoma of the Eyelid.

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a Department of Ophthalmology , Caritas Medical Centre , Hong Kong .
b Department of Ophthalmology , Queen Mary Hospital , Hong Kong , and.
c Department of Surgery , Queen Mary Hospital , Hong Kong.


Muir-Torre syndrome is a rare, autosomal dominant condition characterized by the presence of a skin tumor of sebaceous differentiation and visceral malignancies. We reviewed the case of a 46-year-old Chinese man who had a bleeding mass over the right upper eyelid. He had a history of colon cancer and a family history satisfying the Amsterdam criteria for hereditary non-polyposis colorectal cancer syndrome with germline mutation in the MutS homolog-2 gene. The eyelid lesion was excised completely and submitted for histopathologic examination which showed sebaceous carcinoma. Frozen section and conjunctival map biopsy showed no residual malignancy or local metastasis. Post-operative positron-emission tomography with combined computed tomography did not reveal any residual or visceral malignancy. He had no recurrence in the 32-month follow-up period. We should consider Muir-Torre syndrome in patients with sebaceous carcinoma, especially in the presence of personal and/or family history of visceral malignancies.


Eyelid; Muir-Torre syndrome; hereditary non-polyposis colorectal carcinoma; sebaceous carcinoma; sebaceous tumor

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