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Br J Pharmacol. 2014 Apr;171(8):1870-89. doi: 10.1111/bph.12430.

Mitochondrial protein quality control in health and disease.

Author information

1
Department of Biochemistry and Molecular Biology and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC, Australia; ARC Centre of Excellence for Coherent X-ray Science, Melbourne, VIC, Australia.

Abstract

Progressive mitochondrial dysfunction is linked with the onset of many age-related pathologies and neurological disorders. Mitochondrial damage can come in many forms and be induced by a variety of cellular insults. To preserve organelle function during biogenesis or times of stress, multiple surveillance systems work to ensure the persistence of a functional mitochondrial network. This review provides an overview of these processes, which collectively contribute to the maintenance of a healthy mitochondrial population, which is critical for cell physiology and survival.

KEYWORDS:

apoptosis; mitochondria; mitochondrial morphology; neurodegenerative disease; protease; protein quality control

PMID:
24117041
PMCID:
PMC3976610
DOI:
10.1111/bph.12430
[Indexed for MEDLINE]
Free PMC Article

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