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Genes Dev. 2013 Oct 1;27(19):2072-85. doi: 10.1101/gad.227439.113.

Calorie restriction and sirtuins revisited.

Author information

1
Department of Biology, Glenn Laboratory for the Science of Aging, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

Abstract

Calorie or dietary restriction (CR) has attracted attention because it is the oldest and most robust way to extend rodent life span. The idea that the nutrient sensors, termed sirtuins, might mediate effects of CR was proposed 13 years ago and has been challenged in the intervening years. This review addresses these challenges and draws from a great body of new data in the sirtuin field that shows a systematic redirection of mammalian physiology in response to diet by sirtuins. The prospects for drugs that can deliver at least a subset of the benefits of CR seems very real.

KEYWORDS:

CR mimetics; calorie restriction; sirtuins

PMID:
24115767
PMCID:
PMC3850092
DOI:
10.1101/gad.227439.113
[Indexed for MEDLINE]
Free PMC Article

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