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Dev Dyn. 2014 Jan;243(1):117-31. doi: 10.1002/dvdy.24060. Epub 2013 Nov 7.

Non-transcriptional interactions of Hox proteins: inventory, facts, and future directions.

Author information

1
Institut des Sciences de la Vie, Université catholique de Louvain, Louvain-la-Neuve, Belgium.

Abstract

Hox proteins are conserved homeodomain transcription factors involved in the control of embryo patterning, organ development, and cell differentiation during animal development and adult life. Although recognizably active in gene regulation, accumulating reports support that Hox proteins are also active in controlling other molecular processes like mRNA translation, DNA repair, initiation of DNA replication, and possibly modulation of signal transduction. Here we review experimental evidence as well as databases entries indicative of non-transcriptional activities of Hox proteins.

KEYWORDS:

DNA repair; DNA replication; Hox proteins; interactomics; protein-protein interactions; signaling pathways; translation

PMID:
24115586
DOI:
10.1002/dvdy.24060
[Indexed for MEDLINE]
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