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Am J Ind Med. 2014 Jan;57(1):31-7. doi: 10.1002/ajim.22260. Epub 2013 Sep 20.

High hsCRP is associated with reduced lung function in structural firefighters.

Author information

1
Department of Preventive Medicine, Institute for Translational Epidemiology, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Environmental Health (Environmental and Occupational Medicine and Epidemiology Program), Harvard School of Public Health, Boston, Massachusetts.

Abstract

BACKGROUND:

To assess the association between markers of systemic inflammation and pulmonary function in a population of structural firefighters.

METHODS:

We studied male career members of a large Midwestern fire department with questionnaires, spirometry, and high-sensitivity C-reactive protein (hsCRP) as a biomarker of systemic inflammation. We examined percent predicted forced expiratory volume in 1 s (FEV1 %-predicted) and forced vital capacity (FVC%-predicted).

RESULTS:

Complete data were available for 401 firefighters. Higher hsCRP levels were associated with lower lung function values, after adjusting for confounding variables. Specifically, for every twofold increase in log10-hsCRP, FEV1 %-predicted decreased by a mean 1.5% (95% CI: 0.4, 2.6%) and FVC%-predicted decreased by a mean 1.4% (95% CI: 0.4, 2.3%).

CONCLUSION:

hsCRP as a biomarker of systemic inflammation may indicate reduced lung function in structural firefighters.

KEYWORDS:

high-sensitivity C-reactive protein (hsCRP); percent predicted forced expiratory volume in 1 s (FEV1%-predicted); percent predicted forced vital capacity (FVC%-predicted)

PMID:
24115029
DOI:
10.1002/ajim.22260
[Indexed for MEDLINE]
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