Format

Send to

Choose Destination
Nat Rev Drug Discov. 2013 Nov;12(11):829-46. doi: 10.1038/nrd4145. Epub 2013 Oct 11.

Metabolic targets for cancer therapy.

Author information

1
1] Université Paris Descartes, Sorbonne Paris Cité, F-75006 Paris, France. [2] Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, F-75006 Paris, France. [3] Gustave Roussy, F-94805 Villejuif, France.

Erratum in

  • Nat Rev Drug Discov. 2013 Dec;12(12):963.

Abstract

Malignant cells exhibit metabolic changes, when compared to their normal counterparts, owing to both genetic and epigenetic alterations. Although such a metabolic rewiring has recently been indicated as yet another general hallmark of cancer, accumulating evidence suggests that the metabolic alterations of each neoplasm represent a molecular signature that intimately accompanies and allows for different facets of malignant transformation. During the past decade, targeting cancer metabolism has emerged as a promising strategy for the development of selective antineoplastic agents. Here, we discuss the intimate relationship between metabolism and malignancy, focusing on strategies through which this central aspect of tumour biology might be turned into cancer's Achilles heel.

PMID:
24113830
DOI:
10.1038/nrd4145
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center