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Epilepsy Behav. 2014 Sep;38:37-42. doi: 10.1016/j.yebeh.2013.08.036. Epub 2013 Oct 7.

Complex metabolically demanding sensory processing in the olfactory system: implications for epilepsy.

Author information

1
Department of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Center for Neuroscience, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Rocky Mountain Taste and Smell Center, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. Electronic address: diego.restrepo@ucdenver.edu.
2
Rocky Mountain Taste and Smell Center, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Department of Family Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
3
Department of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Rocky Mountain Taste and Smell Center, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

Abstract

Although the olfactory system is not generally associated with seizures, sharp application of odor eliciting activity in a large number of olfactory sensory neurons (OSNs) has been shown to elicit seizures. This is most likely due to increased ictal activity in the anterior piriform cortex-an area of the olfactory system that has limited GABAergic interneuron inhibition of pyramidal output cell activity. Such hyperexcitability in a well-characterized and highly accessible system makes olfaction a potentially powerful model system to examine epileptogenesis.

KEYWORDS:

Epilepsy; Olfaction; Olfactory bulb; Piriform

PMID:
24113565
PMCID:
PMC3979506
DOI:
10.1016/j.yebeh.2013.08.036
[Indexed for MEDLINE]
Free PMC Article

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