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Eur Urol. 2014 May;65(5):856-64. doi: 10.1016/j.eururo.2013.09.041. Epub 2013 Oct 3.

A multicentre year-long randomised controlled trial of exercise training targeting physical functioning in men with prostate cancer previously treated with androgen suppression and radiation from TROG 03.04 RADAR.

Author information

1
Edith Cowan University Health and Wellness Institute, Joondalup, WA, Australia. Electronic address: d.galvao@ecu.edu.au.
2
Edith Cowan University Health and Wellness Institute, Joondalup, WA, Australia; Department of Radiation Oncology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia; Faculty of Medicine, University of Western Australia, Nedlands, WA, Australia.
3
School of Medicine and Public Health, University of Newcastle, NSW, Australia; Newcastle Mater Hospital, Newcastle, NSW, Australia.
4
Edith Cowan University Health and Wellness Institute, Joondalup, WA, Australia; School of Environmental and Life Sciences, University of Newcastle, NSW, Australia.
5
Edith Cowan University Health and Wellness Institute, Joondalup, WA, Australia.
6
University of Otago, Wellington, New Zealand.
7
Edith Cowan University Health and Wellness Institute, Joondalup, WA, Australia; Griffith Health Institute, Griffith University, Gold Coast, Australia; Viertel Centre for Research in Cancer Control, Cancer Council Queensland, Brisbane, Australia.

Abstract

BACKGROUND:

Long-term prostate cancer (PCa) survivors are at increased risk for comorbidities and physical deconditioning.

OBJECTIVE:

To determine the effectiveness of a year-long randomised controlled trial of exercise training in PCa survivors >5 yr postdiagnosis on physical functioning.

DESIGN, SETTING, AND PARTICIPANTS:

Between 2010 and 2011, 100 long-term PCa survivors from Trans-Tasman Radiation Oncology Group 03.04 Randomised Androgen Deprivation and Radiotherapy previously treated with androgen-deprivation therapy and radiation therapy were randomly assigned to 6 mo of supervised exercise followed by 6 mo of a home-based maintenance programme (n=50) or printed educational material about physical activity (n=50) for 12 mo across 13 university-affiliated exercise clinics in Australia and New Zealand.

INTERVENTION:

Supervised resistance and aerobic exercise or printed educational material about physical activity.

OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS:

The primary end point was a 400-m walk as a measure of cardiovascular fitness. Secondary end points were physical function, patient-reported outcomes, muscle strength, body composition, and biomarkers. Analysis of covariance was used to compare outcomes for groups at 6 and 12 mo adjusted for baseline values.

RESULTS AND LIMITATIONS:

Participants undergoing supervised exercise showed improvement in cardiorespiratory fitness performance at 6 mo (-19 s [p=0.029]) and 12 mo (-13 s [p=0.028]) and better lower-body physical function across the 12-mo period (p<0.01). Supervised exercise also improved self-reported physical functioning at 6 (p=.006) and 12 mo (p=0.002), appendicular skeletal muscle at 6 mo (p=0.019), and objective measures of muscle strength at 6 and 12 mo (p<0.050). Limitations included the restricted number of participants undertaking body composition assessment, no blinding to group assignment for physical functioning measures, and inclusion of well-functioning individuals.

CONCLUSIONS:

Supervised exercise training in long-term PCa survivors is more effective than physical activity educational material for increasing cardiorespiratory fitness, physical function, muscle strength, and self-reported physical functioning at 6 mo. Importantly, these benefits were maintained in the long term with a home-based programme with follow-up at 12 mo.

CLINICAL TRIAL REGISTRY:

The effect of an exercise intervention on cardiovascular and metabolic risk factors in prostate cancer patients from the RADAR study, ACTRN: ACTRN12609000729224.

KEYWORDS:

Androgen deprivation; Musculoskeletal system; Physical exercise; Physical function; Quality of life; Resistance training

PMID:
24113319
DOI:
10.1016/j.eururo.2013.09.041
[Indexed for MEDLINE]

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