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Curr Biol. 2013 Oct 7;23(19):R880-3. doi: 10.1016/j.cub.2013.08.030.

Rapamycin resistance: mTORC1 substrates hold some of the answers.

Author information

1
Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA. Electronic address: yoonsh@ucmail.uc.edu.

Abstract

The mechanism of action of the mTOR inhibitor rapamycin is poorly understood and why certain mTORC1 phosphorylation sites are rapamycin insensitive remains elusive. Site-specific analysis of mTORC1 substrates now suggests that the sequence composition of a phosphorylation site determines whether it is sensitive to rapamycin and starvation.

PMID:
24112984
DOI:
10.1016/j.cub.2013.08.030
[Indexed for MEDLINE]
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