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Diabet Med. 2014 Mar;31(3):357-65. doi: 10.1111/dme.12332. Epub 2013 Nov 8.

Pregnancy losses in women with Type 1 or Type 2 diabetes in the UK: an investigation using primary care records.

Author information

1
Department of Pharmacy and Pharmacology, University of Bath, Bath, UK.

Abstract

AIM:

This study aims to investigate pregnancy losses in women with Type 1 or Type 2 diabetes and compare this with the general population.

METHODS:

Pregnancies ending between 1993 and 2006 in those with Type 1 or Type 2 diabetes were identified on the General Practice Research Database. Pregnancy losses were identified from medical records and the cohort described by their characteristics and prescribing for diabetes.

RESULTS:

Of 2001 pregnancies identified in women with Type 1 diabetes, 678 ended in a pregnancy loss: 19.6% were spontaneous, 9.6% were induced and 4.3% were losses for unknown reasons. In women with Type 2 diabetes, there were 240 losses in 669 pregnancies: 21.1% were spontaneous, 10.3% induced and 4.0% were losses for unknown reasons. The proportion of spontaneous losses in women with diabetes was higher than in the general population (13.2%). Women with Type 1 diabetes treated with human and analogue insulins were 60% more likely to have a delivery than a loss (odds ratio 1.6, 95% CI 1.18-2.18) compared with human insulin treatment alone, although numbers were small.

CONCLUSION:

We found that the proportions of spontaneous losses in women with Type 1 or Type 2 diabetes were similar at approximately 20%, which is higher than in the general population and also higher than previous studies have reported. While much emphasis has been placed on pre-conception care for women with Type 1 diabetes, the same is now needed for those with Type 2 diabetes, given the similarity in outcomes and increasing prevalence of this condition.

PMID:
24111989
DOI:
10.1111/dme.12332
[Indexed for MEDLINE]

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