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Proc Natl Acad Sci U S A. 1985 Aug;82(16):5255-9.

Identical short peptide sequences in unrelated proteins can have different conformations: a testing ground for theories of immune recognition.

Abstract

The ability of antibodies raised against disordered short peptides to interact frequently with their cognate sequences in intact folded proteins has raised a major theoretical issue in protein chemistry. We propose to address this issue by using antibodies raised against peptides with identical sequences, but different conformations, in pairs of unrelated proteins of known three-dimensional structure. The general search method presented here enabled us to detect candidate sequences for such immunological studies.

PMID:
2410917
PMCID:
PMC390546
DOI:
10.1073/pnas.82.16.5255
[Indexed for MEDLINE]
Free PMC Article

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