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Kidney Int. 2014 Mar;85(3):513-21. doi: 10.1038/ki.2013.374. Epub 2013 Oct 9.

Potential use of biomarkers in acute kidney injury: report and summary of recommendations from the 10th Acute Dialysis Quality Initiative consensus conference.

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Department of Medicine, School of Medicine and Medical Science, University College Dublin, Dublin, Ireland.
Department of Medicine, UCSD Medical Center, University of California San Diego, San Diego, California, USA.
Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA.
Renal Division, St Bortolo Hospital, International Renal Research Institute, Vicenza, Italy.
1] Department of Nephrology, Prince of Wales Clinical School, University of New South Wales, Sydney, New South Wales, Australia [2] Christchurch Kidney Research Group, Department of Medicine, University of Otago, Christchurch, New Zealand.
Department of Critical Care Medicine, School of Medicine, Pittsburgh, Pennsylvania, USA.
Department of Anesthesiology and Critical Care Medicine, George Washington University Medical Center, Washington, DC, USA.
1] Department of Nephrology Dialysis and Transplantation, San Bortolo Hospital, Vicenza, Italy [2] International Renal Research Institute (IRRIV), Vicenza, Italy.
Department of Intensive Care Adults, Erasmus MC University Medical Centre Rotterdam, Rotterdam, The Netherlands.
Division of Nephrology and Center for Immunity, Inflammation and Regenerative Medicine, University of Virginia, Charlottesville, Virginia, USA.


Over the last decade there has been considerable progress in the discovery and development of biomarkers of kidney disease, and several have now been evaluated in different clinical settings. Although there is a growing literature on the performance of various biomarkers in clinical studies, there is limited information on how these biomarkers would be utilized by clinicians to manage patients with acute kidney injury (AKI). Recognizing this gap in knowledge, we convened the 10th Acute Dialysis Quality Initiative meeting to review the literature on biomarkers in AKI and their application in clinical practice. We asked an international group of experts to assess four broad areas for biomarker utilization for AKI: risk assessment, diagnosis, and staging; differential diagnosis; prognosis and management; and novel physiological techniques including imaging. This article provides a summary of the key findings and recommendations of the group, to equip clinicians to effectively use biomarkers in AKI.

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