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J Oral Implantol. 2014 Feb;40(1):110-4. doi: 10.1563/AAID-JOI-D-13-00062. Epub 2013 Oct 9.

Two neglected biologic risk factors in bone grafting and implantology: high low-density lipoprotein cholesterol and low serum vitamin D.

Author information

1
1‚ÄČ Pain Clinic, Nice, France.

Abstract

Following a failure of a bone graft or an implant placement, the hypothesis of a biological abnormality is rarely considered as a possible cause. A systematic search of peer-reviewed literature for dyslipidemia or vitamin D deficiency may explain this lack of consideration. Excess low-density lipoprotein cholesterol (dyslipidemia) is responsible for a slower bone metabolism or lower dental implant osseointegration. In addition, vitamin D is a key factor for linking innate and adaptive immunity. Both of these factors are compromised under the conditions of vitamin D deficiency. Therefore, vitamin D deficiency slows implant osseointegration and increases the risk of graft infection. Vitamin D is also involved in immune function and therefore allergic reactions.

PMID:
24107195
DOI:
10.1563/AAID-JOI-D-13-00062
[Indexed for MEDLINE]

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