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J Int Assoc Provid AIDS Care. 2015 Sep-Oct;14(5):415-22. doi: 10.1177/2325957413504827. Epub 2013 Oct 8.

Differences in Clinical Manifestations of Acute and Early HIV-1 Infection between HIV-1 Subtypes in African Women.

Author information

  • 1Division of Infectious Diseases and HIV Medicine, Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH, USA tracy.lemonovich@uhhospitals.org.
  • 2Division of Infectious Diseases, Akron General Medical Center, Akron, OH, USA.
  • 3Family Health International, Durham, NC, USA.
  • 4Department of Obstetrics and Gynaecology, University of Zimbabwe Medical School, Harare, Zimbabwe.
  • 5Department of Medicine, Makerere University College of Health Sciences, Kampala, Uganda.
  • 6Division of Infectious Diseases and HIV Medicine, Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH, USA.

Abstract

Little is known about the differences in clinical manifestations between women with various HIV-1 subtypes during acute (AI) and early (EI) HIV infection. In a longitudinal cohort study, clinical signs and symptoms among Uganda and Zimbabwe women with AI and EI were compared with HIV-negative controls; symptoms were assessed quarterly for 15 to 24 months. Early HIV infection was defined as the first visit during which a woman tested HIV antibody positive. Women who were HIV negative serologically but DNA polymerase chain reaction positive were considered AI. In all, 26 women were classified AI and 192 EI, with 654 HIV-negative controls. Primary HIV infection (AI and EI) was associated with unexplained fever (P <.01), weight loss (P <.01), fatigue (P <.01), inguinal adenopathy (P <.01), and cervical friability (P =.01). More women with subtype C infection had unexplained fever, fatigue, and abnormal vaginal discharge compared to subtype A or D infection. Inguinal adenopathy occurred less often in women with subtype A infection than those with subtype C or D infection.

KEYWORDS:

HIV-1 subtype; STDs; acute HIV infection; clinical manifestations; women

PMID:
24106054
PMCID:
PMC4511722
DOI:
10.1177/2325957413504827
[PubMed - indexed for MEDLINE]
Free PMC Article
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