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Stroke. 2013 Dec;44(12):3482-9. doi: 10.1161/STROKEAHA.113.002045. Epub 2013 Oct 8.

Intracerebral hematomas disappear on T2*-weighted images during normobaric oxygen therapy.

Author information

1
From the Inserm, UMR-S U919, Serine Proteases and Pathophysiology of the Neurovascular Unit, GIP Cyceron, University Caen Lower-Normandy, Caen, France (T.G., C.G., A.M., V.A., M.R., E.E., D.V., M.G.); and Department of Neurosurgery (T.G., E.E.), Department of Anesthesiology and Critical Care Medicine (M.H.), and Biostatistics and Clinical Research Unit (M.R.), Caen University Hospital, Caen, France.

Abstract

BACKGROUND AND PURPOSE:

The aim of the present study was to investigate the effects of normobaric oxygen (NBO) therapy on T2*-weighted images of intracranial hemorrhages (ICHs).

METHODS:

Two common models of ICH were performed in mice, and longitudinal T2*-weighted images of the hematomas were acquired under normoxia or NBO. The effects of NBO were also investigated on perfusion-weighted imaging, susceptibility-weighted imaging, and molecular imaging of vascular cell adhesion molecule-1 after ICH. Last, we performed neurological testing, including neuroscore, actimetry, and gait analysis (Catwalk), to study the influence of NBO on neurological outcome of mice presenting ICH.

RESULTS:

Our results demonstrated that NBO, even during a short period of time, dramatically reduces the sensitivity of T2*-weighted imaging to detect ICH. Moreover, we provide evidence that the disappearance of ICH on T2*-weighted imaging could be used to improve accuracy of perfusion-weighted imaging and to allow molecular imaging after ICH. Importantly, a 30-minute NBO preparation 24 hours after ICH onset does not influence neurological outcome.

CONCLUSIONS:

We provide an experimental demonstration that NBO significantly affects T2*-weighted imaging in ICH. Although this phenomenon could lead to inaccurate assessment of ICH volume, it could also be safely used to allow perfusion-weighted imaging and molecular imaging.

KEYWORDS:

behavior therapy; cerebral hemorrhage; magnetic resonance imaging; molecular imaging

PMID:
24105700
DOI:
10.1161/STROKEAHA.113.002045
[Indexed for MEDLINE]

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