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Hum Genet. 2014 Jun;133(6):713-25. doi: 10.1007/s00439-013-1373-5. Epub 2013 Oct 9.

Cancer genomics identifies disrupted epigenetic genes.

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1
Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), 3rd Floor, Hospital Duran i Reynals, Av. Gran Vía 199-203, L'Hospitalet, 08907, Barcelona, Catalonia, Spain.

Abstract

Latest advances in genome technologies have greatly advanced the discovery of epigenetic genes altered in cancer. The initial single candidate gene approaches have been coupled with newly developed epigenomic platforms to hasten the convergence of scientific discoveries and translational applications. Here, we present an overview of the evolution of cancer epigenomics and an updated catalog of disruptions in epigenetic pathways, whose misregulation can culminate in cancer. The creation of these basic mutational catalogs in cell lines and primary tumors will provide us with enough knowledge to move diagnostics and therapy from the laboratory bench to the bedside.

PMID:
24104525
DOI:
10.1007/s00439-013-1373-5
[Indexed for MEDLINE]
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