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J Infect. 2014 Jan;68 Suppl 1:S119-24. doi: 10.1016/j.jinf.2013.09.022. Epub 2013 Oct 5.

Bordetella pertussis: why is it still circulating?

Author information

1
Institut Pasteur, Molecular Prevention and Therapy of Human Diseases Unit, Paris, France; Centre National de la Recherche Scientifique (CNRS), URA3012, France. Electronic address: nicole.guiso@pasteur.fr.

Abstract

Bordetella pertussis is the causal agent of whooping cough, a highly contagious respiratory disease that is life-threatening in infants under the age of three months and may also be very severe in pregnant women and seniors. This disease can be prevented by vaccination but it remains a public health problem in many developed and developing countries.(1) So, why is B. pertussis still circulating? We need to consider several aspects of this vaccine-preventable disease when answering this question: (i) the history of the disease and the historical context in which the vaccine was developed; (ii) the type of vaccine used; (iii) the vaccination strategy and coverage; (iv) the disease surveillance after the introduction of generalized vaccination and (v) the surveillance for the causal agent of the disease.

KEYWORDS:

Bordetella pertussis; Diagnostic; Vaccine; Whooping cough

PMID:
24103807
DOI:
10.1016/j.jinf.2013.09.022
[Indexed for MEDLINE]

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