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Biochem Biophys Res Commun. 2013 Nov 1;440(4):640-5. doi: 10.1016/j.bbrc.2013.09.115. Epub 2013 Oct 5.

Analysis of an intronic promoter within Synj2.

Author information

1
Department of Biological Sciences, North Carolina State University, Campus Box 7617, Raleigh, NC 27695, USA. Electronic address: ajplanch@ncsu.edu.

Abstract

Synj2 (synaptojanin 2) encodes an inositol polyphosphate phosphatase that functions in recycling neurotransmitter vesicles and is implicated in spermatogenesis. Transcription of Synj2 is thought to occur from one of two promoters based on analysis of a variable 5' untranslated region. Clustering all known mouse Synj2 transcripts led us to uncover a novel subset of transcripts that appears to derive from a region located within intron 7. We identified two alternate splice variants emanating from use of this promoter. These alternate splice variants manifest developmental stage specificity and somatic versus gametic differences in expression.

KEYWORDS:

Inositol polyphosphate phosphatase; Mouse; Non-canonical promoter; Spermatogenesis; Synaptojanin

PMID:
24103750
PMCID:
PMC5761313
DOI:
10.1016/j.bbrc.2013.09.115
[Indexed for MEDLINE]
Free PMC Article

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