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Libyan J Med. 2013 Oct 7;8:22520. doi: 10.3402/ljm.v8i0.22520.

Rose geranium essential oil as a source of new and safe anti-inflammatory drugs.

Author information

1
Laboratoire Eco-Physiologie Végétale, Département des Sciences Naturelles, Ecole Normale Supérieure de Kouba, Alger, Algeria; Laboratoire Biotechnologies Végétales, Département de Biologie, Université Saad Dahleb de Blida, Algeria; mn.boukhatem@yahoo.fr.

Abstract

BACKGROUND:

Since the available anti-inflammatory drugs exert an extensive variety of side effects, the search for new anti-inflammatory agents has been a priority of pharmaceutical industries.

AIMS:

The aim of the present study was to assess the anti-inflammatory activities of the essential oil of rose geranium (RGEO).

METHODS:

The chemical composition of the RGEO was investigated by gas chromatography. The major components were citronellol (29.13%), geraniol (12.62%), and citronellyl formate (8.06%). In the carrageenan-induced paw edema, five different groups were established and RGEO was administered orally in three different doses.

RESULTS:

RGEO (100 mg/kg) was able to significantly reduce the paw edema with a comparable effect to that observed with diclofenac, the positive control. In addition, RGEO showed a potent anti-inflammatory activity by topical treatment in the method of croton oil-induced ear edema. When the dose was 5 or 10 µl of RGEO per ear, the inflammation was reduced by 73 and 88%, respectively. This is the first report to demonstrate a significant anti-inflammatory activity of Algerian RGEO. In addition, histological analysis confirmed that RGEO inhibited the inflammatory responses in the skin.

CONCLUSION:

Our results indicate that RGEO may have significant potential for the development of novel anti-inflammatory drugs with improved safety profile.

KEYWORDS:

anti-inflammatory effect; carrageenan; citronellol; croton; essential oils; histopathology; rose geranium; skin inflammation

PMID:
24103319
PMCID:
PMC3793238
[Indexed for MEDLINE]
Free PMC Article

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