Four novel HLA alleles, DRB1*04:11:03, DRB1*10:05, DRB1*15:94 and DRB1*16:22, identified in Brazilian individuals

R A Fabreti-Oliveira; E Nascimento; C K F Oliveira; E M G Vale; B Vilela; M A Santos

doi:10.1111/iji.12091

Four novel HLA alleles, DRB104:11:03, DRB110:05, DRB115:94 and DRB116:22, identified in Brazilian individuals

Int J Immunogenet. 2014 Apr;41(2):151-3. doi: 10.1111/iji.12091. Epub 2013 Sep 16.

Authors

R A Fabreti-Oliveira¹, E Nascimento, C K F Oliveira, E M G Vale, B Vilela, M A Santos

Affiliation

¹ Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil; Departamento da Ciência da Computação, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil; IMUNOLAB - Laboratório de, Imunologia de Transplantes, Belo Horizonte, MG, Brazil.

PMID: 24103044
DOI: 10.1111/iji.12091

Abstract

Four novel human leucocyte antigen (HLA) class II alleles were identified by sequencing-based typing (SBT) and analysis of the closest-matching alleles from volunteer subjects from the Brazilian Bone Marrow Donor Register (REDOME, Brazil). The new HLA alleles discovered include DRB1*04:11:03, DRB1*10:05, DRB1*15:94 and DRB1*16:22. Three of the novel alleles had single-nucleotide substitution polymorphisms when compared to their most homologous allele. Of these, one harboured a single-nucleotide polymorphism (SNP) identified as a silent substitution.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alleles
Amino Acid Substitution
Base Sequence
Brazil
Exons
Female
HLA-DRB1 Chains / genetics*
Humans
Male
Molecular Sequence Data
Polymorphism, Single Nucleotide
Tissue Donors

Substances

HLA-DRB1 Chains