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Histopathology. 2013 Dec;63(6):869-76. doi: 10.1111/his.12225. Epub 2013 Sep 16.

Antibodies are forever: a study using 12-26-year-old expired antibodies.

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1
Department of Pathology, AO San Gerardo, Monza, Italy.

Abstract

AIMS:

The aim of this study was to investigate whether the shelf-life of diagnostic antibodies is longer than the expiry date on the label.

METHODS AND RESULTS:

Four independent laboratories tested a small number of diagnostic antibodies kept at +4°C for 12-26 years, and found them to work perfectly on routine histology sections.

CONCLUSIONS:

Diagnostic antibodies may have a workable half-life in excess of 10 years, and the emphasis on performance should shift to the preservation of antigenic targets in the tissue.

KEYWORDS:

antibody; expiry date; immunohistochemistry

PMID:
24102865
DOI:
10.1111/his.12225
[Indexed for MEDLINE]
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