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Genet Test Mol Biomarkers. 2014 Jan;18(1):62-5. doi: 10.1089/gtmb.2013.0357. Epub 2013 Oct 8.

Association of interleukin-6 -174 G>C promoter polymorphism with increased risk of type 2 diabetes mellitus patients with diabetic nephropathy in Turkey.

Author information

1
1 Department of Endocrinology and Metabolism, Sifa University Medical School , Izmir, Turkey .

Abstract

OBJECTIVE:

Diabetic nephropathy (DN) is a serious complication of diabetes mellitus. We aimed to evaluate the interleukin (IL)-6 gene polymorphisms in type 2 DN and control subjects.

MATERIALS AND METHODS:

The patients selected from the Department of Endocrinology and Metabolism Diseases included 43 type 2 diabetes mellitus patients without DN and 43 type 2 diabetes mellitus patients with DN and 340 healthy normal controls. All subjects underwent venous blood drawing for complete hormonal assays, lipid profile, glucose, and insulin and Il-6 gene polymorphism genetic analysis.

RESULTS:

IL-6 -174 G>C genotype distribution was different between the control group and the type 2 diabetes mellitus patients (p=0.004). The higher frequency of the polymorphic G allele was also similar for the group with type 2 diabetes mellitus as for the control group. The frequency of the polymorphic G allele was 83.9% in diabetic patients with nephropathy versus 70.9% in those without nephropathy (p=0.039).

CONCLUSION:

We suggest that the -174 G>C polymorphism of the IL-6 gene is an independent risk factor for DN in Turkish type 2 diabetes mellitus patients.

PMID:
24102240
DOI:
10.1089/gtmb.2013.0357
[Indexed for MEDLINE]

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