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Head Neck Pathol. 2014 Jun;8(2):234-8. doi: 10.1007/s12105-013-0495-3. Epub 2013 Oct 8.

Myeloid sarcoma of the nasopharynx mimicking an aggressive lymphoma.

Author information

1
Clinical Haematology Department, Institut Gustave Roussy (IGR), 114 rue Edouard Vaillant, 94805, Villejuif, France, Raphaeljack13@hotmail.com.

Abstract

BACKGROUND:

Myeloid sarcoma (MS) is a rare extra-medullary tumour of the myeloid lineage, which can be a difficult diagnosis to make.

CASE PRESENTATION:

We report the case of a 73-year-old male with a right-sided nasopharyngeal mass revealed on CT scan and MRI.

RESULTS:

An initial cytological and histological examination suggested a high-grade lymphoma. Nevertheless, the final diagnosis was a MS with an unusual involvement of the nasopharynx that was treated with a conventional induction leukemia therapy. Eight months later, the patient had persistent thrombocytopenia and a bone marrow aspiration showed the dysplasia of a high grade myelodysplastic syndrome and cytogenetics detected t(3;21). The patient was treated with a 5-Azacitidine (Vidaza) protocol until overt progression and disease evolution.

CONCLUSION:

In conclusion few cases of MS involving the nasopharynx have been reported. Its diagnosis is often difficult and should be considered especially when a high index of suspicion is present and the immunophenotype of the malignant haematological cells is not clearly in favour of a lymphoma.

PMID:
24101200
PMCID:
PMC4022928
DOI:
10.1007/s12105-013-0495-3
[Indexed for MEDLINE]
Free PMC Article
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