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Curr Opin Gastroenterol. 2013 Nov;29(6):588-96. doi: 10.1097/MOG.0b013e328365d34d.

Autophagy at the crossroads of metabolism and cellular defense.

Author information

1
aGastrointestinal Unit, Center for the Study of Inflammatory Bowel Disease, Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts bBroad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

Abstract

PURPOSE OF REVIEW:

From its initial description as a homeostatic process required for starvation response, autophagy has emerged as a ubiquitous cellular process involved in a broad range of cellular activities from metabolic adaptation to cellular defense against invading pathogens. This review provides an overview of autophagy and highlights the recent developments in deciphering its role in metabolic adaptation and its importance in antibacterial defense with attention to regulatory pathways.

RECENT FINDINGS:

Within the last 2 years, there has been significant progress in deciphering the mechanisms by which autophagy is regulated, including subcellular localization, posttranslational modifications, and transcriptional control. In addition, the cell type-specific role of autophagy in maintaining cellular homeostasis has been defined, including its role in handling intracellular pathogens and its contribution to inflammatory bowel disease.

SUMMARY:

Autophagy is a critical pathway that integrates numerous regulatory inputs to maintain cellular homeostasis and defend against intracellular pathogens.

PMID:
24100719
DOI:
10.1097/MOG.0b013e328365d34d
[Indexed for MEDLINE]

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