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Hum Genet. 2013 Dec;132(12):1427-31. doi: 10.1007/s00439-013-1375-3. Epub 2013 Oct 8.

No evidence of interaction between known lipid-associated genetic variants and smoking in the multi-ethnic PAGE population.

Author information

1
Center for Human Genetics Research, Vanderbilt University, 2215 Garland Avenue, 515B Light Hall, Nashville, TN, 37232, USA, logan.dumitrescu@chgr.mc.vanderbilt.edu.

Abstract

Genome-wide association studies (GWAS) have identified many variants that influence high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and/or triglycerides. However, environmental modifiers, such as smoking, of these known genotype-phenotype associations are just recently emerging in the literature. We have tested for interactions between smoking and 49 GWAS-identified variants in over 41,000 racially/ethnically diverse samples with lipid levels from the Population Architecture Using Genomics and Epidemiology (PAGE) study. Despite their biological plausibility, we were unable to detect significant SNP × smoking interactions.

PMID:
24100633
PMCID:
PMC3895337
DOI:
10.1007/s00439-013-1375-3
[Indexed for MEDLINE]
Free PMC Article

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