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J Neuroimmunol. 2013 Nov 15;264(1-2):120-2. doi: 10.1016/j.jneuroim.2013.07.017. Epub 2013 Aug 3.

EBNA-1 IgG titers in Sardinian multiple sclerosis patients and controls.

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Dipartimento di Scienze Biomediche, Sezione di Microbiologia e Virologia, Università di Sassari, Italy.


Multiple sclerosis (MS) is thought to be triggered by environmental factors acting on a genetic predisposition. Sardinians share a homogeneous genetic background and boast one of the highest MS prevalence worldwide. We investigated Epstein-Barr virus (EBV) antibody prevalence in Sardinian population by ELISA. Our results show a higher serum prevalence of EBNA-1 IgG in MS patients compared to healthy controls. Moreover, analyzing a subset of patients treated for 6 months with IFN-β, we observed a decrease in their EBNA-1 specific IgG titers. These results confirm previous findings and strengthen the association between EBV and MS in Sardinia.


EBNA-1; Epstein–Barr virus; IFN-β; Multiple sclerosis; Sardinian

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