Format

Send to

Choose Destination
See comment in PubMed Commons below
Int J Biol Macromol. 2013 Nov;62:636-41. doi: 10.1016/j.ijbiomac.2013.09.045. Epub 2013 Oct 4.

Preparation and characterization of pH-responsive guar gum microspheres.

Author information

1
School of Chemistry, Shoolini University, Solan 173229, India.

Abstract

Guar gum, being the natural polymer is renewable, nontoxic, biocompatible and biodegradable. Therefore, it is the perfect material to formulate particulates or microspheres for potential applications in pharmaceutical. The formulation of material in nano/microsphere scale offers new rich in application potential. In view of that, novel biodegradable and pH-sensitive hydrogels composed of pH-sensitive methacrylic acid (MAc) and a biodegradable guar gum were synthesized by grafting reactions. Water-in-oil (w/o) emulsion method was used to direct the pH-sensitive material in microspheres shape using bi-functional glutaraldehyde (GA) as crosslinker. The synthesized microspheres were characterized by FTIR and SEM (different magnification). The swelling ratios of hydrogels in buffer solutions showed a pH-dependent profile at physiological pH. In vitro release data was analyzed using Fick's law, which indicated swelling controlled super case II transport of BSA through the synthesized microspheres. Therefore, in conclusion, as ascertained from the results the introduction of -COOH moieties along the guar gum chain drastically increases the end-use performance due to pH-sensitivity.

KEYWORDS:

Emulsion polymerization; Microspheres; pH-sensitive

PMID:
24099940
DOI:
10.1016/j.ijbiomac.2013.09.045
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center