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Mol Cancer. 2013 Oct 7;12(1):117. doi: 10.1186/1476-4598-12-117.

The T-box transcription factor, TBX3, is sufficient to promote melanoma formation and invasion.

Author information

1
Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town 7925, South Africa. Sharon.prince@uct.ac.za.

Abstract

The T-box transcription factor, TBX3, is overexpressed in several cancers and has been proposed as a chemotherapeutic target. Several lines of evidence suggest that TBX3 may be a key contributor to malignant melanoma, a highly aggressive and intractable disease. Using in vitro and in vivo assays we demonstrate here for the first time that overexpressing TBX3 in non-tumourigenic early stage melanoma cells is sufficient to promote tumour formation and invasion. Furthermore, we show that TBX3 may play an important role as a reciprocal switch between substrate dependent cell proliferation and tumour invasion.

PMID:
24098938
PMCID:
PMC3851469
DOI:
10.1186/1476-4598-12-117
[Indexed for MEDLINE]
Free PMC Article

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